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Neoline, also known as Bullatine B, is an active ingredient that suppresses Nav1.7 Electrical Flow Control (VGSC). It has been studied for its potential to improve mechanical pain sensitivity in diabetes and for its role in pain management.
Significantly reduces Nav1.7 VGSC current induced by depolarization in HEK293 cells (IC50 of 25.8 nM).
Ameliorates oxaliplatin-induced peripheral neuropathy in vivo.
Inhibits paclitaxel- or partial sciatic nerve injury-induced allodynia in a mouse model.
Shows an antinociceptive effect and raises the mechanical nociceptive threshold in diabetic mice.
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